Virus protease



Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.

3D Structures of Virus proteases
Update June 2011

HIV-1
3ixo - HIV1-PR subtype A

1odx, 2hb2,  2hb4,  2pc0 - HIV1-PR (mutant)

1rpi, 1rq9,  1tw7 - HIV1-PR (drug-resistant mutant)

1odw, 3kf1 - HIV1-PR

HIV-1 complexes
1hsg, 1hsh,  1hsi,  3oxc,  3ekv,  3ekx,  3eky,  3el1,  1ohr - HIV1-PR + antiviral drug

1aid, 1qbr,  1qbs,  1qbt,  1qbu,  3mxe,  3m9f,  3kf0,  3kf1,  3kfn,  3kfp,  3kfr,  3kfs,  2wkz,  2wl0,  3gga,  3ggv,  3ggx,  2uxz,  2uy0,  1zp8,  1xl2,  1xl5,  1zpa,  1yt9,  2a4f ,  1upj,  2upj,  7upj,  1hxb,  1hih,  1hvr,  1hef,  1heg,  4phv,  1w5w,  1w5x,  1w5v,  1w5y,  1t7k,  1npa,  1npv,  1npw,  1eby,  1ec0,  1g2k,  1c6x,  1c6y,  1c6z,  1hwr,  2bpv,  2bpw,  2bpx,  2bpy,  2bpz,  1ody,  1hvh,  3tlh,  1hxw - HIV1-PR + inhibitor

2zye - HIV1-PR + inhibitor - neutron

3aid, 1ytg,  1yth,  2nxd,  2nxl,  2nxm,  2fns,  2fnt,  1zj7,  1zlf,  1zpk,  1zsf,  1zsr, 1cpi, 1m0b,  1iiq,  1fqx,  1a30 - HIV1-PR + polypeptide derivative

1sp5 - HIV1-PR + autoproteolytic peptide

HIV-1 (mutant) complexes
3nu3, 3nu4,  3nu5,  3nu6,  3nu9,  3nuj,  3nuo,  2qhc,  2qak,  2pym,  2pyn,  2q63,  2q64,  2fxd,  2fxe,  2fgu,  2fgv,  1sdt,  1sdu,  1sdv,  1d4y,  1d4s - HIV1-PR (mutant) + antiviral drug

2aid, 1hpo,  1tcx,  1gnm,  1gnn,  1gno,  1kzk,  3ok9,  3i8w,  3i7e,  3bxr,  3bxs,  2hc0,  2psu,  2psv,  2fle,  2f3k,  2ien,  2fdd,  2fde,  1t7i,  1t3r,  1mrw,  1mrx,  1msm,  1msn,  1bv9 - HIV1-PR (mutant) + inhibitor

2p3b - HIV1-PR subtype B (mutant) + inhibitor

2p3c - HIV1-PR subtype F (mutant) + inhibitor

1zbg, 1z8c,  2az9,  2azc,  2a1e,  1lzq,  1d4k,  1d4l,  1a8k,  1a94,  1axa - HIV1-PR (mutant) + polypeptide derivative

1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane

HIV-1 (drug-resistant mutant) complexes
3el4, 3el9,  3em3,  3em4,  3em6,  3ggt,  3ggu,  1t7j,  1rv7,  1n49,  1fb7 - HIV1-PR (drug-resistant mutant) + antiviral drug

1izh, 1izi,  1fb7 - HIV1-PR (drug-resistant mutant) + inhibitor

2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor

2p3d - HIV1-PR subtype F (drug-resistant mutant) + inhibitor

HIV-2
1jld - HIV2-PR

1hii - HIV2-PR + inhibitor

5upj, 6upj,  3upj,  4upj - HIV2-PR (mutant) + inhibitor

1ida, 1idb,  2mip - HIV2-PR + polypeptide derivative

Feline Immunodeficiency Virus-PR
2hah, 4fiv - FIV-PR residues 39-154 (mutant) + inhibitor

5fiv, 6fiv,  1b11 - FIV-PR + inhibitor

2fiv, 3fiv - SIV-PR (mutant) + substrate

Simian Immunodeficiency Virus-PR
2sam - SIV-PR + inhibitor

1az5 - SIV-PR (mutant)

XMRV-PR
3nr6 – XMRV-PR P14

3p1g – XMRV-PR RNase H domain (mutant)

Rous sarcoma virus protease
1bai – RSVP + polypeptide inhibitor _ Rous sarcoma virus

Human Cytomegalovirus protease
1cmv, 1lay – CMVP (mutant) – human herpes virus 1wpo – CMVP 2wpo - CMVP (mutant) + inhibitor

Varicella-Zoster virus protease
1vzv - VZVP (mutant) – human herpes virus

Equine infectious anemia virus protease
2fmb – EIAVP (mutant) + inhibitor

Hepatitis A virus protease
2h9h – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor